Research and Development is not Marketing There are no conditions to this NO, as Kaneka scientists created a product from strain cultivation to fermentation to encapsulation to packaging, with one thing in mind: providing you with a clinically-tested strain in the amounts needed to provide you with an effect as demonstrated in published scientific studies. Another prevalent misconception: Probiotics have to be refrigerated.Īfter your probiotics have reached home, many people may wonder if there’s a need to refrigerate Floradapt probiotics. Probiotic researchers at the cutting edge of their field will be the first people to inform you that the efficacy of a probiotic is based on its activity demonstrated in a clinical environment. It’s not a numbers game it is a strain game. It’s such a pervasive myth that we will have to come back to this topic from time to time to reinforce the truth. Before we jump into our new target, let’s run up the score and remind people again: The efficacy of a probiotic is completely unrelated to CFU count or the number of strains in the product. In our last blog, you read that the bacterial CFU (colony forming unit) counts are completely unrelated to the activity mediated by the probiotic. "Using zebrafish, we've developed a relatively inexpensive platform for testing of other species of bacteria and probiotics and their potential benefit on different systems of the body," Ericsson says.Which Probiotic Myth Will We Lay to Rest This Time? Once the fish were administered probiotics, they tended to spend more time toward the top of the tanks-the change in behavior indicating they were less stressed or less anxious. Previous studies of fish behavior have found that fish that are stressed tend to spend more time at the bottom of their tanks. To test their theory further, the researchers measured the movements of fish in their tanks using sophisticated computer measuring and imaging tools. "Essentially, bacteria in the gut altered the gene expression associated with stress- and anxiety-related pathways in the fish allowing for increased signaling of particular neurotransmitters." "By measuring the genes associated with stress and anxiety, our tests were able to predict how this common probiotic is able to benefit behavioral responses in these fish," says Daniel Davis, PhD, assistant director of the MU Animal Modeling Core. "These are common environmental stress patterns, such as isolation stress and temperature change, so it made the tests relevant to humans as well."īy analyzing the gene pathways of both groups of fish, the research team found that zebrafish that were given the supplements showed a reduction in the metabolic pathways associated with stress. "Each day we introduced a different stressor-tests that are validated by other researchers and cause higher anxiety among zebrafish," says Elizabeth Bryda, PhD, a professor of veterinary pathobiology in the MU College of Veterinary Medicine. Then, the researchers introduced environmental stressors to both groups, such as draining small amounts of water from the tank and overcrowding. In the first study, scientists added the bacteria to certain tanks housing zebrafish other tanks of zebrafish received no probiotics. In a series of studies, researchers tested how zebrafish behaved after doses of Lactobacillus plantarum, a common bacteria found in yogurt and probiotic supplements. ![]() ![]() ![]() "Our study has shown that simple probiotics that we normally use to keep our digestive tract in sync, could be beneficial to reducing our stress levels as well." "Zebrafish are an emerging model species for neurobehavioral studies and their use is well established in drug screening," says Aaron Ericsson, DVM, PhD, director of the MU Metagenomics Center and an assistant research professor in the department of veterinary pathobiology. Their results were published in Scientific Reports, a journal of Nature. Studying how gut bacteria affect behavior in zebrafish could lead to a better understanding of how probiotics may affect the central nervous system in humans. Now, researchers at the University of Missouri (MU), using a zebrafish model, determined that a common probiotic sold in supplements and yogurt can decrease stress-related behavior and anxiety. ![]() Studies have shown a direct correlation between gut microbes and the central nervous system. Probiotics Can Reduce Stress and Anxiety Levels
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